Mechanism of Cellular Interaction, Binding and Internalization of Functionalized Carbon Nanotubes

نویسندگان

  • L. Lacerda
  • M. Prato
  • A. Bianco
  • K. Kostarelos
چکیده

The interaction between cells and carbon nanotubes (CNT) is a critical issue that will determine any future biological application of such structures. In this communication we will show that various types of functionalized-carbon nanotubes (f-CNT) exhibit a capacity to be uptaken by a wide range of cells (prokaryotic and eukaryotic) and can intracellularly traffick through different cellular barriers . The mechanism by which f-CNT are able to cross cell membranes and deliver their cargo will also be discussed. Energy-independent mechanisms are explained based on the cylindrical shape and high aspect ratio of f-CNT that can allow their penetration through the plasma membrane, similar to a ‘nanosyringe’.

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تاریخ انتشار 2008